The Week’s 10 Biggest Funding Rounds: Enterprise AI, Space Tech And Biotech Top The Ranks

Want to keep track of the largest startup funding deals in 2025 with our curated list of $100 million-plus venture deals to U.S.-based companies? Check out The Crunchbase Megadeals Board. This is a weekly feature that runs down the week’s top 10 announced funding rounds in the U.S. Check out last week’s biggest funding deal roundup here. Another week, another infusion of big AI rounds. For this past week, the largest fundraiser by a long shot was Sierra, a developer of AI customer experience tools that picked up $950 million. Other big rounds went to companies in sectors including satellite development, biotech, and, yes, more vertical AI and AI infrastructure. 1. Sierra, $950M, customer experience AI: Sierra, a provider of AI-driven tools for customer experience management, raised $950 million in fresh funding at a $15 billion valuation. Google Ventures and Tiger Global led the financing for the three-year-old, San Francisco-based company. 2. Astranis, $455M, space tech: Astranis, a developer of advanced satellites for high orbits, secured $450 million in equity and debt investment. The financing included a $300 million Series E equity round led by Snowpoint Ventures and Franklin Templeton and up to $155 million in credit through Trinity Capital. 3. Anagram Therapeutics, $250M, biotech: Natick, Massachusetts-based Anagram Therapeutics, a developer of a pill for people living with exocrine pancreatic insufficiency due to cystic fibrosis, pancreatic cancer and related disorders, closed on $250 million in new funding from Blackstone Life Sciences. 4. Blitzy, $200M, AI software development: Blitzy, developer of an autonomous software development platform, picked up $200 million in fresh funding at a $1.4 billion valuation. Northzone led the financing for the Cambridge, Massachusetts-based company. 5. Corgi Insurance, $160M, insurance: Corgi Insurance, provider of an AI-native insurance platform for startups, secured $160 million in Series B funding. TCV led the financing, which set a $1.3 billion valuation for the San Francisco-based company. 6. Panthalassa, $140M, renewable energy: Portland, Oregon-based Panthalassa, which aims to perform AI inference computing at sea using power generated from ocean waves, raised $140 million in a Series B financing led by Peter Thiel. 7. Reserv, $125M, insurance: Reserv, a provider of third-party administrator services to the insurance industry, closed on $125 million in a Series C funding round led by KKR. Launched in 2022, New York-based Reserv has raised over $200 million in known funding to date, per Crunchbase data. 8. DeepInfra, $107M, AI infrastructure: DeepInfra, a cloud platform for high-throughput AI inference, landed $107 million in Series B funding. Georges Harik and 500 Global led the financing for the four-year-old, Palo Alto, California-based company. 9. Tessera Labs, $60M, vertical AI: San Jose, California-based Tessera Labs, developer of an AI platform for enterprise ERP systems and data, secured $60 million in a funding round led by Andreessen Horowitz. 10. Astrocade, $56M, gaming: Astrocade, developer of an AI platform for creating, building and playing games, announced $56 million in new funding. The funding for the Los Altos, California-based company includes a Series B led by Sequoia Capital and a Series A led by Sea, Astrocade said. Illustration: Dom Guzman